Persistent itching, hard nodules, and now new treatment options – modern biologics bring real relief for Prurigo Nodularis

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• What is Prurigo Nodularis?

• What causes Prurigo Nodularis?

• What treatment options have been available?

• A breakthrough: modern biologic therapies

• How does the treatment work?

What is Prurigo Nodularis?

Prurigo Nodularis is a chronic inflammatory skin condition that causes severe and persistent itching together with hard, nodular skin lesions. Continuous scratching leads to thick, crusted bumps – often on the arms, legs, or torso.
The itch can be so intense that it disrupts sleep, concentration, and overall quality of life. Many patients suffer for years before receiving an accurate diagnosis and effective treatment.

What causes Prurigo Nodularis?

The exact cause is complex and involves both nerve and immune system overactivity in the skin. This overreaction keeps the itch–scratch cycle going. Prurigo Nodularis often occurs in people with atopic dermatitis (eczema), liver or kidney disorders, or allergies.
Stress, anxiety, and emotional strain can further aggravate symptoms, creating a frustrating vicious circle.

What treatment options have been available?

For decades, treatment options were limited. Patients were usually prescribed topical corticosteroid creams, moisturizers, or phototherapy (light treatment).
Antihistamines, while commonly used for itching, have little effect on Prurigo Nodularis, since the itch is not caused by histamine.

As a result, many people continued to suffer from severe, chronic itch despite consistent therapy.

A breakthrough: modern biologic therapies

Finally, there is hope. New biologic medications ((Dupilumab and Nemolizumab) now offer targeted treatment that directly addresses the root cause of Prurigo Nodularis. These therapies block specific inflammatory messengers in the immune system responsible for the constant itch and inflammation.

Many patients experience a significant reduction in itching within just a few weeks, along with smoother skin, better sleep, and an overall improvement in quality of life.

Biologics represent a real revolution in dermatology – offering relief where creams and light therapy have failed.

How does the treatment work?

After a thorough dermatological diagnosis and medical assessment, the treatment plan is tailored to each individual. Depending on the severity of symptoms, biologics can be combined with topical anti-inflammatory care, moisturizers, and light therapy for optimal results.

At the Dermatology Center at Vienna Central Station (Dermatologie am Hauptbahnhof Wien), we specialize in modern dermatological treatments and are among the first clinics in Austria to offer biologic therapy for Prurigo Nodularis.
Our goal is to reduce the chronic itch, heal the skin, and restore comfort and confidence.

We will gladly advise you in person about all possibilities and you are welcome to Book your appointment here.

In summary

• Chronic inflammatory skin condition with severe itching and nodular lesions

• Traditional therapies: corticosteroids, light therapy, and antihistamines – often with limited success

• Biologic therapy: targeted, effective, and long-lasting relief

• Noticeable improvement in itching and quality of life

Do you suffer from chronic itching or hard nodules on your skin?
Book an appointment at our clinic in Vienna – we will discuss the newest biologic treatments for Prurigo Nodularis and help you regain calm, healthy skin and restful sleep.

FAQ – Prurigo Nodularis

Here you will find answers to the most frequently asked questions about prurigo nodularis, chronic itch, and modern biologic therapies that finally provide targeted relief.

We will gladly advise you in person about all possibilities and you are welcome to Book your appointment here.